Hyaluronan
نویسندگان
چکیده
منابع مشابه
Developing fluorescent hyaluronan analogs for hyaluronan studies.
Two kinds of fluorescent hyaluronan (HA) analogs, one serving as normal imaging agent and the other used as a biosensitive contrast agent, were developed for the investigation of HA uptake and degradation. Our approach of developing HA imaging agents depends on labeling HA with varying molar percentages of a near-infrared (NIR) dye. At low labeling ratios, the hyaluronan uptake can be directly ...
متن کاملHyaluronan and hyaluronan synthases: potential therapeutic targets in cancer.
Current models of oncogenesis describe cancer as a progression of genetic mutations in a tumor cell mass. However, tumors are more than a clonal expansion of malignant cells. Tumors are heterogeneous, with a complex 3D structure, analogous to organs comprised of different tissues. In a tumor mass, the component cell types interact with each other and with their microenvironment by exchanging in...
متن کاملRole of hyaluronan and hyaluronan-binding proteins in lung pathobiology.
Hyaluronan (HA) has diverse functions in normal lung homeostasis and pulmonary disease. HA constitutes the major glycosaminoglycan in lung tissue, with HA degradation products, produced by hyaluronidase enzymes and reactive oxygen species, being implicated in several lung diseases, including acute lung injury, asthma, chronic obstructive pulmonary disease, and pulmonary hypertension. The differ...
متن کاملExpression of hyaluronan synthases and hyaluronan in malignant mesothelioma cells.
BACKGROUND Hyaluronan is one of the main components of the extracellular matrix. It is synthesized at the cell plasma membrane by specific hyaluronan synthases (HAS). Although a large number of studies have described hyaluronan in pleural effusion from malignant mesothelioma, the source of hyaluronan in malignant mesothelioma has been subject to controversy. MATERIALS AND METHODS The mRNA exp...
متن کاملDomain motions of hyaluronan lyase underlying processive hyaluronan translocation.
Hyaluronan lyase (Hyal) is a surface enzyme occurring in many bacterial organisms including members of Streptococcus species. Streptococcal Hyal primarily degrades hyaluronan-substrate (HA) of the extracellular matrix. This degradation appears to facilitate the spread of this bacterium throughout host tissues. Unlike purely endolytic degradation of its other substrates, unsulfated chondroitin o...
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ژورنال
عنوان ژورنال: Journal of Histochemistry & Cytochemistry
سال: 2015
ISSN: 0022-1554,1551-5044
DOI: 10.1369/0022155415576542